WHAT IS CBD?

Cannabidiol—CBD—is a cannabis compound that has significant medical benefits, but does not make people feel “stoned” and can actually counteract the psychoactivity of THC.
The fact that CBD-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria.

Cannabidiol, also known as CBD is the name of one of the most numerous compounds found in the cannabis plant. Cannabinoids are a class of active chemical compounds produced by the cannabis plant that are found throughout the seeds, stalk, and flowers of cannabis plants — including hemp and marijuana. These cannabinoids act on receptors located in our cells as part of the endocannabinoid system (ECS) and alter the release of neurotransmitters from body organs, including the brain. The ECS predominantly consists of two endocannabinoid receptors: CB1, located in the central nervous system (CNS), and CB2, found throughout the peripheral nervous system (PNS). Researchers are currently discovering new receptors and are now uncovering that there may be more CB receptors inside of our body.

CBD is the main active compound in hemp and unlike THC, CBD it is not psychoactive, so it does not make you high. Hemp plants have substantial amounts of CBD and only trace amounts of THC which has led to it becoming more popularly recognized for its medicinal purposes. Researchers have been able to identify numerous therapeutic uses of CBD. CBD hemp oil is a natural botanical concentrate.

Scientific and clinical research—much of it sponsored by the US government—underscores CBD’s potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders. CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere. Further evidence suggests that CBD is safe even at high doses.

Inside the human body there’s the endocannabinoid system, with receptors spread throughout the brain and body. Cannabinoid receptors are involved in a series of processes inside the human body, including the regulation of mood, pain sensation, appetite and memory. These receptors can be activated by endocannabinoids produced by the human body as well as by plant cannabinoids and they’re grouped in two main categories: CB1 and CB2. CB1 receptors are found mostly in the central nervous system, and in smaller numbers in the liver, kidneys and lungs, while CB2 receptors are part of the immune system and found in the hematopoietic blood cells as well [1]. It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids. It has been shown that Cannabidiol (CBD) strengthens and improves the efficacy of mitochondria, the power source for every cell in your body.

Continued studies on the Endocannabinoid System (ECS) have shown that apart from being regulator of homeostasis, the ECS also responsible for repairing damaged cells. Research has also shown that cannabinoids are able to target damaged cells without affecting normal cells, which means that the ECS can act as a biological defense system. When a person ingests hemp oil, CBD, or other cannabinoids, these cannabinoid receptors are activated (CBD seems to have a higher affinity for CB2 receptors than CB1 receptors). Research is showing that supplementing your Endocannabinoid System with plant cannabinoids, you are naturally developing a healthier ECS system and improving the power source of your body’s cells.

Johnson, Jon. (2017, April). CBD oil: Uses, health benefits, and risks. Retrieved from www.medicalnewstoday.com

Source: Article published by Medical News Today; Reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT.

CBD MISCONCEPTIONS

With the growing awareness of CBD as a potential health aid there’s also been a proliferation of misconceptions. Find questions and responses to common misinformation.

CBD doesn’t get you high

ϖ No, CBD doesn’t get you high. CBD is an active compound within hemp as well as the whole cannabis plant. It contains no psychoactive effects as compared to THC. You might be wondering how this is possible. It’s because your association of cannabis is to the marijuana plants bread for high THC content – the specific cannabinoid that gets you high. However, cannabis contains many other cannabinoids – most of which do not get you high, like CBD. Some cannabis plants are bred for high CBD content exclusively – these plants are known as ‘hemp’ – and only contain trace amounts of THC (below 0.3% to be exact). The combination of high-CBD with extremely low amounts of THC is what makes the products derived from hemp plants non-psychoactive.

CBD is medical. THC is recreational.

Project CBD receives many inquiries from around the world and oftentimes people say they are seeking “CBD, the medical part” of the plant, “not THC, the recreational part” that gets you high. Actually, THC, “The High Causer,” has awesome therapeutic properties. Scientists at the Scripps Research Center in San Diego reported that THC inhibits an enzyme implicated in the formation of beta amyloid plaque, the hallmark of Alzheimer’s-related dementia. The federal government recognizes single-molecule THC (Marinol) as an anti-nausea compound and appetite booster, deeming it a Schedule III pharmaceutical, a category reserved for drugs with little abuse potential. But whole plant cannabis, which is the only natural source of THC, continues to be classified as a dangerous Schedule I drug with no medical value.

THC is the bad cannabinoid. CBD is the good cannabinoid.

The drug warrior’s strategic retreat: Give ground on CBD while continuing to demonize THC. Diehard marijuana prohibitionists are exploiting the good news about CBD to further stigmatize high-THC cannabis, casting tetrahydrocannabinol as the bad cannabinoid, whereas CBD is framed as the good cannabinoid. Why? Because CBD doesn’t make you feel high like THC does. Project CBD categorically rejects this moralistic, reefer madness dichotomy in favor of whole plant cannabis therapeutics. (Read the foundational science paper: A Tale of Two Cannabinoids.)

CBD is most effective without THC

THC and CBD are the power couple of cannabis compounds—they work best together. Scientific studies have established that CBD and THC interact synergistically to enhance each other’s therapeutic effects. British researchers have shown that CBD potentiates THC’s anti-inflammatory properties in an animal model of colitis. Scientists at the California Pacific Medical Center in San Francisco determined that a combination of CBD and THC has a more potent anti-tumoral effect than either compound alone when tested on brain cancer and breast cancer cell lines. And extensive clinical research has demonstrated that CBD combined with THC is more beneficial for neuropathic pain than either compound as a single molecule.

Single-molecule pharmaceuticals are superior to ‘crude’ whole plant medicinals

According to the federal government, specific components of the marijuana plant (THC, CBD) have medical value, but the plant itself does not have medical value. Uncle Sam’s single-molecule blinders reflect a cultural and political bias that privileges Big Pharma products. Single-molecule medicine is the predominant corporate way, the FDA-approved way, but it’s not the only way, and it’s not necessarily the optimal way to benefit from cannabis therapeutics. Cannabis contains several hundred compounds, including various flavonoids, aromatic terpenes, and many minor cannabinoids in addition to THC and CBD. Each of these compounds has specific healing attributes, but when combined they create what scientists refer to as a holistic “entourage effect” or “ensemble effect,” so that the therapeutic impact of the whole plant is greater than the sum of its single-molecule parts. The Food and Drug Administration, however, isn’t in the business of approving plants as medicine. (See the scientific evidence.)

CBD is not psychoactive

CBD is not an intoxicant, but it’s misleading to describe CBD as non-psychoactive. When a clinically depressed patient takes a low dose of a CBD-rich sublingual spray or tincture and has a great day for the first time in a long time, it’s apparent that CBD is a powerful mood-altering compound. Better to say, “CBD is not psychoactive like THC,” than to simply assert that CBD is not psychoactive. CBD won’t make a person feel stoned, but it can impact a person’s psyche in positive ways. Moderate doses of CBD are mildly energizing (“alerting”). But very high doses of CBD may trigger a biphasic effect and can be sleep-promoting. If CBD-rich cannabis flower confers a sedating effect, it’s likely because of a myrcene-rich terpene profile. Myrcene is a terpene with sedative and painkilling properties. CBD is not a sedative.

Psychoactivity is inherently an adverse side effect.

According to politically correct drug war catechism, the marijuana high is an unwanted side effect. Big Pharma is keen on synthesizing medically active marijuana-like molecules that don’t make people high—although it’s not obvious why mild euphoric feelings are intrinsically negative for a sick person or a healthy person, for that matter. In ancient Greece, the word euphoria meant “having health,” a state of well-being. The euphoric qualities of cannabis, far from being an unwholesome side effect, are deeply implicated in the therapeutic value of the plant. “We should be thinking of cannabis as a medicine first,” said Dr. Tod Mikuriya, “that happens to have some psychoactive properties, as many medicines do, rather than as an intoxicant that happens to have a few therapeutic properties on the side.”

High doses of CBD work better than than low doses

CBD isolates require higher doses to be effective than whole plant CBD-rich extracts. But that doesn’t mean single-molecule CBD is a better therapeutic option than CBD-rich cannabis, which has a wider therapeutic window than an isolate. Reports from clinicians and patients suggest that a synergistic combination of CBD, THC, and other cannabis components can be effective at low doses – as little as 2.5 mg CBD and/or 2.5 mg THC. Some patients may require significantly higher doses to obtain satisfactory results. Keep in mind that CBD and THC and cannabis in general have biphasic properties, meaning that low and high doses can produce opposite effects. An excessive amount of CBD could be less effective therapeutically than a moderate dose.

CBD converts to THC in a person’s stomach

Orally administered CBD is well-tolerated in humans. But concerns about possible harmful side effects, which might limit CBD’s therapeutic utility and market potential, were raised by misleading reports that CBD converts to high-causing THC in the stomach. It does not (read the evidence). There have been extensive clinical trials demonstrating that ingested CBD—even doses above 600 mg—does not cause THC-like psychoactive effects. (On the contrary, CBD in sufficient amounts can lessen or neutralize the THC high.) The World Health Organization studied the issue and gave CBD a clean bill of health in a 2017 report that asserted: “Simulated gastric fluid does not exactly replicate physiological conditions in the stomach [and] spontaneous conversation of CBD to delta-9-THC has not been demonstrated in humans undergoing CBD treatment.”

Legalizing CBD, but not cannabis, adequately serves the patient population

Nineteen U.S. states have enacted “CBD only” (or, better said, “low THC” or “no THC”) laws. And 28 states have legalized medical marijuana (not just CBD) in one form or another. Some states restrict the sources of CBD-rich products and specify the diseases for which CBD can be accessed; others do not. But a CBD-rich remedy with little THC doesn’t work for everyone. Parents of epileptic children have found that adding some THC (or THCA, the raw, unheated version of THC) helps with seizure control. For some epileptics, THC-dominant products are more effective than CBD-rich products. Most patients are not well served by CBD-only laws. They need access to a broad spectrum of whole plant cannabis remedies, not just low THC medicine. One size doesn’t fit all with respect to cannabis therapeutics, and neither does one compound or one product or one strain. (Read more: Prohibition’s Last Gasp: “CBD Only”)

Marijuana prohibition doesn’t apply to CBD. CBD is federally legal if it comes from the seed or stalk of hemp

Nice try, but CBD can’t be pressed or extracted from hempseed. CBD can be extracted from the flower tops, leaves, and, only to a very minor extent (if at all) from the stalk of the hemp plant. Hemp oil companies lack credibility when they say their CBD comes from hempseed and stalk. Congress may soon vote to exempt industrial hemp and CBD from the definition of “marihuana” under the Controlled Substances Act. (CSA). Until that happens, cannabis prohibition remains the law of the land, federally speaking. We can’t interpret our way out of the Controlled Substances Act; it must be abolished. Rooted in reefer madness racism and enforced disproportionately against people of color, marijuana prohibition is akin to the Confederate statue still standing – a testament to enduring bigotry and chronic social injustice.

CBD is CBD—It doesn’t matter where it comes from

ϖ Some low resin industrial hemp cultivars may be a feasible source of CBD, but fiber hemp is by no means an optimal source of CBD. Industrial hemp typically contains far less cannabidiol than CBD-rich cannabis flower tops (marijuana). Huge amounts of industrial hemp are required to extract a small amount of CBD, thereby raising the risk of contaminants because hemp is a “bio-accumulator” that draws toxins from the soil. But the debate over sourcing CBD is quickly becoming moot, as plant breeders focus on developing high-resin cannabis varietals (marijuana) that satisfy the legal criteria for industrial hemp – with THC measuring less than 0.3 percent and CBD levels exceeding 10 percent by dry weight. Meanwhile, “pure” CBD synthesized in a lab or extracted and refined from industrial hemp lacks critical medicinal terpenes and other plant compounds that interact with CBD and THC to enhance their therapeutic benefit.

Benefits of CBD And Usages

CBD-rich cannabis has a long history of being used to treat health problems. CBD oil has been traditionally used for thousands of years to treat various types of pain, but it has only recently begun to be studied again by the medical community.
https://www.healthline.com/health/cbd-oil-for-pain
https://www.marijuanabreak.com/best-cbd-oils-pain-relief

Medical marijuana has been used to treat a variety of ailments and conditions since ancient times. However, CBD oil is a prevalent topic in today’s medical field and has profound effect on children with seizures and shrinking tumors. The following is an overview of the incredible positive effects CBD oil has had.

Using CBD dates back to the 19th century. Queen Victoria would use cannabis to alleviate menstrual cramp and relied on it frequently. However, CBD has always played second fiddle to its fellow cannabinoid THC (which gives cannabis its psychoactive properties). In the 1980s, studies hinted that CBD could alleviate certain types of pain, anxiety and nausea, but still did not get much attention until the 90s.
In 1998, a medical company called GW Pharmaceuticals based in Great Britain began to cultivate cannabis for medical trials. Their aim was to develop a concise and consistent plan for extracting CBD. Geoffery Guy, one of the company’s founders, staunchly believed that cannabis plants rich in CBD would be used as medicine. This research would lead to scientific studies conducted by the International Cannabinoid Research Society, Society of Cannabis Clinicians, and International Association for Cannabinoid Medicine. Early animal studies showed that CBD lessened anxiety and reduced the frequency and severity of seizures. This turned heads in the medical community, and cannabis strains began to be cultivated with extremely low levels of THC and high levels of CBD. By 2009, Oakland, California’s Steep Hill Laboratory had successfully grown strains that contained more CBD than THC.
In the 2010s, the public began to see what a profound effect CBD oil could have treating a variety of life-threatening ailments, especially in children. A prime example of this is a young family from Missoula, Montana, using CBD oil to treat their 20-month-old son, Cash Hyde, who had been diagnosed with brain cancer in 2010. Hyde’s condition was worsening and his tumor was inoperable. After exhausting every treatment option, including 30 rounds of intensive radiation, ketamine, methadone and morphine treatments, the Hyde family had hit their limit. Nothing had worked. In an effort to give his small child some relief, Mike Hyde (Cash’s father), did what was thought to be “crazy” at the time and administered a highly concentrated cannabis extract to his son not knowing what else to do.. After his first cannabis treatment, Hyde’s stage IV brain tumor had shrunk. Although it was considered unorthodox, Mike Hyde was applauded by medical professionals and even spoke with the press in hopes of shedding light on how CBD oil is literally a lifesaver (Vice). Cash Hyde lived for another two and a half years passing away after the state of Montana made a change in legislation that impaired the family from easily accessing the cannabis oil their son needed.

Perhaps the most prolific case of CBD oil and its success is the 2013 story that achieved national press. Charlotte Figi is a 3-year-old Colorado girl who suffered 300 grand mal seizures every week. Like the Hyde family, her parents thought they had tried everything including a heavy regimen of pharmaceutical drugs and painful procedures that still did not ease her condition. Her parents had watched a documentary of one of the first medical marijuana dispensaries in California centered around testing their strains for CBD and other cannabinoid content. The California center testing was one of the first public assertions that cannabis was safe to ingest and use for a variety of medical purposes. CBD-rich oil was able to treat 99% of the young girl’s seizures, and CNN aired a 2013 special on marijuana and its medicinal effects.
These are just a couple of specific instances that show how effective CBD oil can be, laying the groundwork for CBD oil being recognized as a justifiable medicine for a variety of ailments. As a result, many states are passing legislation rapidly allowing CBD oil to be used in numerous clinical studies and as treatment plans. Research continues to back up its legitimacy and programs are being funded globally to continue studies.

WHOLE PLANT HEMP EXTRACT VS. CBD ISOLATE

When it comes to purchasing hemp and CBD products, one is presented with a dizzying array of options at hand and a number of terms to understand before making a decision. One of the biggest question is: Do you want to use a whole plant extract, or a CBD isolate? Let’s break it down!

Whole Plant Hemp Extract

Whole plant hemp extracts contain ALL of the available cannabinoids within the hemp material used to create your product. These extracts are also commonly known as full spectrum extracts. They may contain any combination of CBD, CBD-A, THC, THC-A, CBG, and so on. Note, that the cannabinoids present may be altered by the extraction and processing techniques used (ex: decarboxylating the hemp to create a CBD product instead of one with CBD-A).
Legally speaking, the only restriction on whole plant hemp products is that they must contain less than, or equal to, 0.3% THC by weight. Anything over 0.3% THC by weight is considered a marijuana product; for which you need a medical marijuana card in the state of California.
Why is THC beneficial? The cannabinoids in whole plant extracts act in synergy, which increases the potential number of medical conditions that the extract may treat. This is called the “Entourage Effect”: essentially, where 1 + 1 = 3. The small allowed amount of THC in hemp products is not believed to cause a psychoactive “high.” In fact, CBD will attach to your CB1 receptor, (where THC also binds) to create a high, but in reverse; thus decreasing psychoactivity. This is similar to how THCV works as an appetite suppressant, as opposed to THC, which gives you the munchies.
A disadvantage of whole plant hemp extract is that because it does contain trace amounts of THC, these may build up in a user’s system over time, posing a liability in drug testing and other screening.
*** All of our products are made from Whole Plant Hemp Extract. And contain less than 0.3% of THC.

CBD Isolate

CBD isolates contain 99.9% cannabidiol and 0.1% water — they contain 0% THC and no other cannabinoids. They are also referred to as single molecule cannabinoid products. The advantage is that one can use these and pass a THC drug test. However, without the entourage effect, CBD isolates have a more narrow therapeutic window; they are more hit-or-miss, and thus, generally less effective. But for conditions that respond well to CBD isolate, it can be just as therapeutic as a whole plant extract. There are several epileptic conditions where CBD isolate has shown to be extremely helpful.
Hemp can be obtained from low-resin cannabis, which is traditional hemp; tall and stalky, great for rope. It can also be attained from high-resin cannabis, which is traditional marijuana that has been bred down in THC to less than 0.3%. It takes a lot of the former hemp type to create CBD isolates, so beware of hemp that is grown overseas or in unregulated markets. Low-resin, traditional hemp is a very efficient bio-accumulator, meaning it sucks up toxins and other compounds from the soil. In fact, hemp was planted to clean up heavily contaminated soil after the 1986 nuclear disaster at the Chernobyl power plant in Ukraine.
You don’t want your hemp products to come from low-resin hemp due to the risk of bio-accumulated toxins. Instead, look for US-grown high-CBD hemp from high-resin plants (traditional marijuana cultivars). They don’t carry the high risk of bio-accumulation and also take less raw material to create your product, which is more earth-friendly.

LEGALITY OF HEMP OIL :

DEA TAKES SOME CBD OFF SCHEDULE 1
– WITH FDA APPROVAL

The DEA has moved cannabidiol (CBD) drugs (prescription products) with a THC content below .01% to a Schedule 5 (V) drug, provided the drug has been approved by the FDA. Schedule V drugs, substances, or chemicals are defined as drugs with lower potential for abuse than Schedule IV and consist of preparations containing limited quantities of certain narcotics. Schedule V drugs are generally used for antidiarrheal, antitussive, and analgesic purposes.
For more information, please visit:
https://mjbizdaily.com/dea-moves-cbd-medicines-off-schedule-1-a-limited-expansion-of-cannabis-access/
https://potstocknews.com/cbd-schedule-5-drug/

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